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Neoadjuvant Chemotherapy and Ipilimumab For Stage II-IIIA Non-Small Cell Lung Cancer

Objective of this Therapy Area Insight Immune therapy is increasingly becoming an effective treatment for non-small cell lung cancer (NSCLC). The Objective of this study is to determine the percentage of early stage NSCLC patients with detectable circulating T cells specific against tumor-associated antigen (TAA) after receiving platinum based neoadjuvant chemotherapy plus ipilimumab before surgery.…

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Charles Meyer
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Objective of this Therapy Area Insight

Immune therapy is increasingly becoming an effective treatment for non-small cell lung cancer (NSCLC). The Objective of this study is to determine the percentage of early stage NSCLC patients with detectable circulating T cells specific against tumor-associated antigen (TAA) after receiving platinum based neoadjuvant chemotherapy plus ipilimumab before surgery.

small cell lung cancer

TOP1201 Clinical Trial

‘TOP1201’ an open label phase II trial was conducted to evaluate the safety and feasibility of neoadjuvant chemotherapy plus ipilimumab followed by surgery as a treatment strategy for stage II-IIIA non-small cell lung cancer.

Intervention

Adjuvant (Post-Surgery): Ipilimumab

10 mg/kg IV every 3 weeks times 2 doses beginning 4 weeks postoperative

Neoadjuvant (Pre-Surgery)

10 mg/kg IV over 90 minutes, Paclitaxel 175 mg/m2 IV over 3 hours, followed by Cisplatin 75 mg/m2 IV over 60 minutes or carboplatin AUC 6 IV over 30-60 minutes on day 1

Paclitaxel, Cisplatin, Carboplatin Neoadjuvant (Pre-Surgery)

Paclitaxel, Cisplatin, Carboplatin Neoadjuvant (Pre-Surgery) Cycle 1: Paclitaxel 175 mg/m2 IV over 3 hours, followed by Cisplatin 75mg/m2 IV over 60 minutes or carboplatin AUC 6 IV over 30-60 minutes on day 1

Results

Conclusion – The use of neoadjuvant ipilimumab with chemotherapy before surgical resection of stageII-IIIA NSCLC was found to be safe and feasible

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    Charles Meyer

    HealthTech entrepreneur driven by a lifelong passion to build game-changing products to improve global healthcare. MedSynapse is an online community of doctors that helps them connect and collaborate with each other for a better patient outcome.
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